Outstanding Science - 2022
Dr. Brian M. Baker
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA
Authors: Smita S Chandran, Jiaqi Ma, Martin G Klatt, Friederike Dundar, Chaitanya Bandlamudi, Pedram Razavi, Hannah Y Wen, Britta Weigelt, Paul Zumbo, Si Ning Fu, Lauren B Banks, Fei Yi, Enric Vercher, Inaki Etxeberria, Watchain D Bestman, Arnaud Da Cruz Paula, Ilinca S Aricescu, Alexander Drilon, Doron Betel, David A Scheinberg, Brian M Baker, Christopher A Klebanoff.
Abstract: Outstanding Science Award (2022)
Previous Years Outstanding Science:
- 2021 - Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease;
- Authors: Authors: Alejandro Alvarez-Quilon, Jessica L Wojtaszek, ..., R Scott Williams, Daniel Durocher.
- 2020 - A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy;
- Authors: Authors: Jessica L Wojtaszek, Nimrat Chatterjee, Javaria Najeeb, ..., Michael T Hemann, Jiyong Hong, Graham C Walker, Pei Zhou.
- 2020 - Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation;
- Authors: Lan Wu, Edward Seung, ..., Zhi-yong Yang, Gary J. Nabel.
- 2019 - Crystal Structure of the Labile Complex of IL‐24 with the Extracellular Domains of IL‐22R1 and IL‐20R2;
- Authors: Lubkowski J, Sonmez C, Smirnov SV, Anishkin A, Kotenko SV, Wlodawer A.
- 2018 - Visualizing Multistep Elevator-like Transitions of a Nucleoside Transporter;
- Authors: Marscha Hirschi, Zachary Lee Johnson, Seok-Yong Lee.
- 2017 - Observing cellulose biosynthesis and membrane translocation in crystallo;
- Authors: Jacob L. W. Morgan, Joshua T. McNamara, ..., Jochen Zimmer.
- 2016 - Crystal Structure of Human Glycine Receptor-α3 Bound to Antagonist Strychnine;
- Authors: Xin Huang, Hao Chen, Klaus Michelsen, Stephen Schneider, Paul L. Shaffer.
- 2015 - Structure of a Naegleria Tet-like Dioxygenase in Complex With 5-methylcytosine DNA;
- Authors: Hideharu Hashimoto, June E Pais, ..., Yu Zheng, Xiaodong Cheng.
- 2014 - Observing a DNA Polymerase Choose Right from Wrong;
- Authors: Bret D. Freudenthal, William A. Beard, David D. Shock, Samuel H. Wilson.
- 2013 - Structural Basis for Iron Piracy by Pathogenic Neisseria;
- Authors: Nicholas Noinaj, Nicole C. Easley, ..., Susan K. Buchanan.
- 2012 - Structure of HIV-1 gp120 V1/V2 Domain with Broadly Neutralizing Antibody PG9;
- Authors: Jason S. McLellan, Marie Pancera, ..., Peter D. Kwong
- 2011 - G domain Dimerization Controls Dynamin’s Assembly-stimulated GTPase Activity;
- Authors: Joshua S. Chappie, Sharmistha Acharya, Marilyn Leonard, Sandra L. Schmid, Fred Dyda.
- 2010 - Structure of ERA in Complex with the 3′end of 16SrRNA: Implications for Ribosome Biogenesis;
- Authors: Chao Tu, Xiaomei Zhou, ..., Xinhua Ji.
- 2009 - Midbody Targeting of the ESCRT Machinery by a Noncanonical Coiled Coil in CEP55;
- Authors: Hyung Ho Lee, Natalie Elia, Rodolfo Ghirlando, Jennifer Lippincott-Schwartz, James H. Hurley.
- 2008 - Structural Basis for Transcription Elongation by Bacterial RNA Polymerase;
- Authors: Dmitry G Vassylyev, Marina N Vassylyeva, ... Irina Artsimovitch.
- 2008 - Structural Basis for Substrate Loading in Bacterial RNA Polymerase;
- Authors: Dmitry G Vassylyev, Marina N Vassylyeva, ..., Robert Landick.
- 2007 - Outer Membrane Active Transport: Structure of the BtuB:TonB Complex;
- Authors: David D Shultis, Michael D Purdy, Christian N Banchs, Michael C Wiener.
- 2006 - Role of Active Site Water Molecules and Substrate Hydroxyl Groups in Oxygen Activation by Cytochrome P450 158A2: A New Mechanism of Proton Transfer;
- Authors: Bin Zhao, F Peter Guengerich, Markus Voehler, Michael R Waterman.
- 2005 - Error-prone Replication of Oxidatively Damaged DNA by a High-Fidelity DNA Polymerase;
- Authors: Gerald W Hsu, Matthias Ober, Thomas Carell, Lorena S Beese.
Young Investigator - 2022
Dr. Ian Pavelich
Molecular mechanism regulating transcriptional control of the hig toxin‐antitoxin locus of antibiotic-resistance plasmid Rts1 from Proteus vulgaris
Authors: Ian Pavelich, Marc A. Schureck, Dongxue Wang, Eric D. Hoffer, Michelle Boamah, Nina Onuoha, Stacey J. Miles, C. Denise Okafor, Christine M Dunham.
Abstract: Young Investigator Award (2022)
Previous Years Young Investigator:
- 2021 - Disruption of evolutionarily correlated tRNA elements impairs accurate decoding;
- Authors: Ha An Nguyen, S Sunita, Christine M Dunham.
- 2020 - no award
- 2019 - Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap‐Core Interface of HIV‐1 Protease;
- Authors: Andres Wong-Sam, Yuan-Fang Wang, Ying Zhang, Arun K Ghosh, Robert W Harrison, Irene T Weber.
- 2019 - Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI‐6;
- 2018 - Tethering Not Required: The Glucocoricoid Receptor Binds Directly to Activator Protein-1 Recognition Motifs to Repress Inflammatory Genes;
- Authors: Emily R. Weikum, Ian Mitchelle S. de Vera, ..., Eric A. Ortlund.
- 2017 - Oxygen activation at the active site of a fungal lytic polysaccharide monooxygenase;
- Authors: William B O'Dell, Pratul K Agarwal, Flora Meilleur.
- 2016 - Defining the mRNA recognition signature of a bacterial toxin protein;
- Authors: Marc A. Schureck, Jack A. Dunkle, Tatsuya Maehigashi, Stacey J. Miles, Christine M. Dunham
- 2015 - no award
- 2014 - Structure of the Integral Membrane Protein CaaX ProteaseSte24p;
- Authors: Edward E Pryor Jr, Peter S Horanyi, ..., Michael C Wiener, Mark E Dumont.
- 2013 - Repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2;
- Authors: Matthew J Schellenberg, C Denise Appel, ..., R Scott Williams.
- 2012 - Structural basis for RNA recognition by NusBand NusE in the initiation of transcription antitermination;
- Authors: Jason R. Stagno, Amanda S. Altieri, ..., Xinhua Ji.
- 2011 - Crystal Structure of the Phage T4 RecombinaseUvsX and Its Functional Interaction with theT4 SF2 Helicase UvsW;
- Authors: Stefan Gajewski, Michael R. Webb, ..., Kenneth N. Kreuzer, Stephen W. White.
- 2010 - no award
- 2009 - Structural basis for executioner caspase recognition of P5 positionin substrates;
- Authors: Guoxing Fu, Alexander A Chumanevich, Johnson Agniswamy, Bin Fang, Robert W Harrison, Irene T Weber.
- 2008 - Structure of Dnmt3a Bound to Dnmt3L Suggests a Model for De Novo DNA Methylation;
- Authors: Da Jia, Renata Z. Jurkowska, Xing Zhang, Albert Jeltsch, Xiaodong Cheng.
- 2007 - Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11;
- Authors: Ping Liu, Hosam E. Ewis, Phang C. Tai, Chung-Dar Lu, Irene T. Weber.
- 2006 - Structural Insight into the Mechanismof Double-Stranded RNA Processing by Ribonuclease III;
- Authors: Jianhua Gan, Joseph E. Tropea, ..., Xinhua Ji.
- 2005 - Crystal Structure of A. fulgidus Rio2 Defines a New Family of Serine Protein Kinases;
- Authors: Nicole LaRonde-LeBlanc, Alexander Wlodawer.